Alarms and operator response are one of the first layers of defense in preventing a plant upset from escalating into an abnormal situation. The new ISA 18.2 standard on alarm management recommends following a lifecycle approach similar to the existing ISA84/IEC 61511 standard on functional safety. This paper will highlight where these lifecycles interact and overlap, as well as how to address them holistically. Specific examples within ISA 18 will illustrate where the output of one lifecycle is used as input to the other, such as when alarms identified as a safeguards during a process hazards analysis (PHA) are used as an input to alarm identification and rationalization. The paper will also provide recommendations on how to integrate the safety and alarm management lifecycles.